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You shouldn't use codeine In case you have extreme breathing complications, a blockage as part of your belly or intestines, or Regular bronchial asthma assaults or hyperventilation.

Right after halting a CYP3A4 inducer, as the results of the inducer decline, codeine plasma concentrations may maximize, with subsequently increased metabolism by cytochrome CYP2D6, resulting in bigger morphine amounts (see CLINICAL PHARMACOLOGY), which could enhance or prolong both equally the therapeutic results and adverse reactions, and could bring about severe respiratory melancholy.

Overestimating the acetaminophen and codeine phosphate tablets dosage when converting patients from A further opioid merchandise may lead to a lethal overdose with the first dose.

To scale back the chance of dizziness and lightheadedness, rise up slowly and gradually when climbing from a sitting or lying posture.

Codeine crosses the blood-brain barrier and is also found in fetal tissue and breast milk. The plasma focus won't correlate with brain concentration or relief of agony. Codeine is about seven to twenty five% bound to plasma proteins and doesn't accumulate in human body tissues.

Observe for respiratory despair, Primarily throughout initiation and adhering to any rise in dose; near monitoring might be needed in patients at improved danger and/or These receiving concomitant remedies that enhance the hazard of respiratory despair

Reserve concomitant prescribing of acetaminophen and codeine phosphate tablets and benzodiazepines or other CNS depressants for use in patients for whom alternate therapy alternatives are inadequate (see Safeguards, Drug Interactions).

Individuals need to fully grasp the threats of lifetime-threatening respiratory melancholy and when this hazard is biggest, sufferers must be mindful that a genetic mutation could bring about greater toxicity in a few sufferers; individuals and caregivers ought to be instructed to obtain emergency help instantly if far too much drug is taken or if breathing problems happen.

Advise patients and caregivers that probably lethal additive effects could take place if acetaminophen and codeine phosphate tablets are applied with benzodiazepines or other CNS depressants, such as Liquor, instead of to make use of these medications concomitantly Unless of course supervised by a healthcare service provider (see WARNINGS and Safeguards, Drug Interactions).

If a CYP3A4 inducer is discontinued, take into consideration acetaminophen and codeine phosphate tablets dosage reduction and evaluate individuals at frequent intervals for signs of respiratory depression and website sedation.

Respiratory despair can happen Anytime throughout opioid therapy, specially when initiating and following dosage will increase with acetaminophen and codeine phosphate tablets. Consider this possibility when selecting an initial dose and when generating dose adjustments (see WARNINGS).

pregnant or intending to grow to be Expecting. Extended use of Acetaminophen and Codeine here Phosphate Tablets, USP through pregnancy could cause withdrawal symptoms as part of your newborn toddler that can be lifestyle-threatening Otherwise read more acknowledged and treated.

Opioid Analgesic REMS: To make sure that the more info many benefits of opioid analgesics outweigh the threats of addiction, get more info abuse, and misuse, a REMS is required for these products. Below the requirements from the REMS, drug organizations with accredited opioid analgesic merchandise ought to make REMS-compliant teaching programs accessible to Health care vendors.